Alterations in a gene linked to stress reactions may eventually help clinicians identify patients at increased risk for suicidal behavior, including attempts, potentially by way of a simple blood test, new research shows. Investigators at the Johns Hopkins University School of Medicine in Baltimore, Maryland, examined postmortem brains and found a genetic and epigenetic link between suicide and the single- nucleotide polymorphism (SNP) rs7208505 “within the 3′ untranslated region of the SKA2 gene.” The investigators were able to then replicate this finding in 2 other postmortem brain cohorts and in blood draws from 3 live participant cohorts. They found a significantly lower SKA2 gene expression in those with suicidal behavior and an association with variations of rs7208505. A final analysis, this time of salivary cortisol, showed that SKA2 variations may modulate cortisol suppression. The study was published July 30 in the American Journal of Psychiatry.
0 15 diciembre, 2014
Posted in Psiquiatría y psicología by qubitoz